Sulfamethazine
Fa'amatalaga Autu:
Igoa o oloa: Sulfamethazine
Fa'aigoa: sulfadimethylpyrimidine
Fua fa'atatau ole vaila'au: C12H14N4O2S
Fua fa'atatau:
mamafa mole: 278.33
Numera saini CAS: 57-68-1
Numera ulufale a le EINECS: 200-346-4
Fa'aletino ma kemisi
Malosi: 1.392g/cm3
Liu liusuavai: 197°C
Mea e fa'apuna ai: 526.2ºC
Itu ole moli: 272.1ºC
Fa'aaliga: pa'epa'e tioata pa'epa'e
Solubility: toetoe lava a le mafai ona solu i le vai, e le mafai ona solu i le eter, faigofie ona solu i le dilute acid po'o le dilute alkali solution.
Sulfadiazine o se vailaʻau faʻamaʻi sulfanilamide faʻatasi ma alaleo antibacterial tutusa i le sulfadiazine. E i ai a'afiaga antibacterial i siama enterobacteriaceae e pei ole non-zymogenic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, ma isi Neisseria gonorrhoea, Neisseria meningitidis ma Haemophilus influenzae. Ae ui i lea, ua faateleina le tetee o siama i le oloa, aemaise streptococcus, Neisseria ma Enterobacteriaceae siama. Sulfonamides o vailaʻau faʻamaʻi lautele lautele, tutusa i le fausaga o le p-aminobenzoic acid (PABA), lea e mafai ona faʻatauvaʻa faʻatauvaʻa i luga o le dihydrofolate synthetase i siama, ma puipuia ai le PABA mai le faʻaaogaina e fai ma mea mata e faʻapipiʻi ai le folate e manaʻomia e siama ma faʻaitiitia ai le aofaʻi o tetrahydrofolate e fa'agaioia metabolic. O le mea mulimuli o se mea taua mo le tuʻufaʻatasia o purines, thymidine nucleosides ma le deoxyribonucleic acid (DNA), o lea e taofia ai le tuputupu ae ma le toe gaosia o siama.
E masani ona fa'aaogaina mo fa'ama'i mama'i e mafua mai siama ma'ale'ale, e pei ole fa'ama'i fa'ama'i i lalo ole urinary tract, fa'ama'i otitis ma fa'ama'i pa'u vaivai.
