Folasaga
Nucleosides, o poloka faufale o nucleic acids (DNA ma le RNA), e iai sona sao taua i mea ola uma. E ala i le suia o nei molelaʻau, ua tatalaina e saienitisi le tele o faʻaoga talafeagai i suʻesuʻega ma vailaʻau. I lenei tusiga, o le a tatou suʻesuʻeina nisi o faʻaoga autu onucleosides suia.
Le Matafaioi a Nucleosides Fa'afouina
O nucleosides ua suia e faia e ala i le suia o le fausaga o nucleosides masani, e pei o le adenosine, guanosine, cytidine, ma le uridine. O nei suiga e mafai ona aofia ai suiga i le faavae, suka, poʻo mea uma e lua. O le fausaga ua suia e mafai ona tuʻuina atu mea fou i le nucleoside ua suia, ma faʻaoga talafeagai mo faʻaoga eseese.
Talosaga Autu
Su'esu'ega Fualaau Fa'asaina:
Su'ega fa'ama'i: Ua fa'aaogaina nucleosides ua suia e atia'e ai le tele o vaila'au fa'ama'i. Mo se faʻataʻitaʻiga, e mafai ona mamanuina e faʻalavelave ai le faʻasologa o DNA poʻo le taulaʻi o sela o le kanesa patino.
Antiviral agents: O nucleosides ua fa'aleleia e fa'aogaina e fai ai vaila'au fa'ama'i e mafai ona fa'alavelaveina le toe faia o fa'ama'i. O le faʻataʻitaʻiga sili ona taʻutaʻua o le faʻaaogaina o nucleosides faʻaleleia i tui COVID-19 mRNA.
Antibacterial agents: O nucleosides ua suia ua faʻaalia foi le folafolaga i le atinaʻeina o vailaʻau fou.
Inisinia Genetic:
tui mRNA: Nucleosides ua suia o vaega taua ia o tui mRNA, aua e mafai ona faʻaleleia le mautu ma le immunogenicity o le mRNA.
Antisense oligonucleotides: O nei molelaʻau, ua mamanuina e fusifusia i faʻasologa mRNA faʻapitoa, e mafai ona faʻaleleia e faʻaleleia ai lo latou mautu ma faʻapitoa.
Fa'ata'ita'iga o le kenera: E mafai ona fa'aogaina nucleosides ua suia e fai ai oligonucleotides fa'aleleia mo le fa'aogaina o le fa'aogaina o kenera, e pei o le fa'asa'oina o fa'aletonu o le kenera.
Meafaigaluega su'esu'e:
Nucleic acid su'esu'e: Su'ega nucleosides e mafai ona tu'ufa'atasia i su'esu'ega fa'aogaina i auala e pei ole fluorescence in situ hybridization (FISH) ma su'esu'ega microarray.
Aptamers: O nei nucleic acids e tasi-stranded e mafai ona fesuiaʻi e fusifusia i sini faʻapitoa, e pei o polotini poʻo mole mole laiti, ma e iai faʻaoga i suʻesuʻega ma togafitiga.
Fa'amanuiaga o Nucleosides Fa'afouina
Faʻaleleia le mautu: O nucleosides ua suia e mafai ona faʻaleleia atili le mautu o nucleic acids, faʻamalosia atili ai i latou i le faʻaleagaina e enzymes.
Fa'atupula'ia fa'apitoa: O suiga e mafai ona fa'aleleia atili ai le fa'apitoa o feso'ota'iga nucleic acid, e mafai ai ona fa'amanino atili fa'atatauga mole mole ola.
Faʻaleleia le faʻaogaina o le telefoni feaveaʻi: O nucleosides ua suia e mafai ona mamanuina e faʻaleleia ai le faʻaogaina o le telefoni feaveaʻi, faʻateleina lo latou aoga i faʻaoga togafitiga.
Fa'ai'uga
O nucleosides ua suia ua suia ai matā'upu eseese, mai le su'esu'eina o vaila'au i le inisinia fa'ainisinia. O latou agavaʻa ma gafatia e faʻafetaui mo faʻaoga faʻapitoa e avea ai i latou ma meafaigaluega taua mo tagata suʻesuʻe ma fomaʻi. A'o fa'aauau pea ona fa'atupula'ia lo tatou malamalama i le kemisi nucleic acid, e mafai ona tatou fa'amoemoe e va'ai nisi fa'aoga fou o nucleosides ua suia i le lumana'i.
Taimi meli: Aukuso-20-2024